Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical/ published results.
What is Sermorelin? Sermorelin is a small peptide molecule that is a form of growth hormone releasing factor (GRF). GRF molecules that are produced by neurosecretory neurons in the brain each contain 44 amino acids each. Sermorelin molecules, on the other hand, contain only the first 29 amino acids because research has shown that it is only these first 29 amino acids that are responsible for stimulating pituitary production and secretion of HGH. Indeed, Sermorelin is sometimes referred to as GRF 1-29 NH-2 - with the 1-29 reflecting the reduced number of amino acids. Sermorelin should not be confused with HGH. It is not simply HGH by a different name but something entirely different. Sermorelin is what is known as a growth hormone secretagogue. In other words, Sermorelin stimulates the pituitary gland in to producing and secreting HGH. And, whereas Sermorelin is only a small peptide molecule with 29 amino acids, HGH is a much larger molecule that contains no less than 191 amino acids.
How does Sermorelin work? One of the main advantages of Sermorelin is the way in which it works. It specifically binds to the cells that produce and release HGH. Once bound, Sermorelin initiates its action in exactly the same way as naturally occurring growth hormone releasing hormone. This results in the production and release of HGH. In other words, Sermorelin effectively mimics the body’s natural processes that lead to an increase in HGH levels.
How Should I Take Sublingual Sermo-Pro? Unlike Human Growth Hormone injections Sermorelin is easy to administer and can be stored at room temperature. A dropper full of Sermorelin each evening held under the tongue for 60 seconds before swallowing is all that’s required.
When should people take sermorelin and what kinds of doses are normal? It has been suggested that sermorelin be taken at bedtime based upon the fact that GHRH (as well as sermorelin) is known to increase slow wave, restful deep sleep in some people. Such sleep is associated with the large nocturnal bursts of hGH from the pituitary gland. However, in others, sermorelin induced GH release before sleep results in increased mental activity and may actually delay sleep onset. Thus, depending upon specific patient results, those who benefit with improved sleep quality from sermorelin should take it at bedtime. Otherwise, morning or daytime administration is appropriate. No specific time is better than another unless sleep architecture is improved. Regarding dosage, patient specificity again is the most important consideration. Efficacy has been reported with subcutaneous doses as low as 0.2 mg daily; whereas some patients need as much as 1 or 2 mg daily to gain desirable results. Because sublingual bioavailability is less than that achieved by subcutaneous administration, the higher dose range of 1 – 2 mg of sermorelin daily is recommende
Does Sermorelin have any other benefits that extend beyond stimulating HGH? Aside from stimulating HGH production, research indicates that Sermorelin may also have a direct effect on the brain when it comes to promoting non-REM slow wave sleep. Slow wave sleep is often referred to as deep sleep and it plays a vital role in our overall well-being. Deprivation of this sleep state can lead to many unpleasant feelings of depression, grogginess, feeling overwhelmed and general malaise. Unfortunately, as the brain grows older, it starts to have trouble staying in this sleep state or even reaching it all. Therefore, being able to promote this type of deep sleep can have profoundly positive effects as we grow older.
What Are the Benefits of Having Higher HGH Levels? HGH has the ability to reduce subcutaneous fat, which is the fat found just below the skin. It has also been clinically proven to increase lean muscle mass, enable faster repair to damaged parts of the body, increase stamina and promote a general increase in rate of metabolism.
Why Sermorelin rather than HGH? The simple fact of the matter is that Sermorelin produces the same benefits as HGH such as reduced subcutaneous fat, increased muscle mass and increased stamina but it does so without producing any of the problems that we’ve outlined above that can occur when dealing with HGH alone. In particular, safety concerns over being exposed to too much HGH are minimised with Sermorelin. The effects of Sermorelin are regulated by a negative feedback system and the release of the hormone somatostatin. Somatostatin (also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF) is a peptide hormone whose job it is to regulate the endocrine system. The endocrine system is the name given to the system of glands within the body that are responsible for secreting different hormones into the bloodstream. In the case of Sermorelin and HGH, we are specifically concerned with the pituitary gland - a small pea sized gland that sits near the base of the brain. Although it is only about one centimetre in size, the pituitary gland is often referred to as the master gland because it makes and stores hormones that influence other glands in the body. In other words, the pituitary gland effectively conducts the endocrine system. Somatostatin works to ensure that Sermorelin does not lead to too much HGH production. Therefore, because of these regulating factors, the safety concerns associated the HGH overdosing are minimized or completely avoided when using Sermorelin. In fact, Sermorelin has an excellent safety profile.
Why use Sermorelin when you can purchase over-the counter HGH secretagogues? Having established just what a superior product Sermorelin is, you may be wondering why it is necessary to go to the trouble of getting a prescription for it when there are other HGH secretagogues available for purchase over the counter. But you should be aware that these products are not the same as Sermorelin. Instead, they are usually amino acids such as L-dopa, L-Arginine and L-glutamine and while high doses of these compounds may indeed lead to HGH being released by the pituitary gland, their effect is non-specific. They have a general effect on brain activity and as they do not work through any specific receptors on the pituitary gland, their effects are often intermittent and may be unreliable. If you add to this the fact that high doses of amino acids can produce kidney problems, you can easily see why such products are inferior to Sermorelin.
Do you experience a loss of potency when taking Sermorelin over time? We mentioned above the fact that something called tachphylaxis does not occur when using Sermorelin. Tachphylaxis is the medical term given to the rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. If you continuously use HGH supplementation for a period of six months or more then you are in real danger of tachphylaxis. As a result many users of HGH supplements find that after such a period of time, they experience a real loss of HGH potency. Unlike naturally occurring daily episodic spikes in HGH, injected HGH increases blood levels of the hormone to unnaturally high levels for several hours each day. In addition, continuous use of HGH also leads to elevated IGF-1 production which in turn means that tissues are exposed to IGF-1more than they would normally be. The combination of these factors results in target tissue receptors down regulating themselves. They do this in order to try to prevent over stimulation that would be caused by exposure to the unnaturally high levels of both HGH and IGF-1 created by the continuous use of HGH supplementation over a period of time. This manifests itself to the user as an apparent loss of potency as response to the HGH supplementation appears to decrease i.e. tachphylaxis occurs. But this does not happen when you use Sermorelin. Sermorelin acts on the pituitary gland in a way that mimics the natural workings of the body. As mentioned above, the normal, naturally occurring release of HGH is episodic throughout the day. This means that on a daily basis, levels of HGH increase and then fall a number of times. When levels drop, tissue receptors get a chance to rest before being stimulated again. Over stimulation does not occur and there is no need for the receptors to down regulate. And because Sermorelin works in a similar episodic way, there is no tachphylaxis and therefore no loss of potency even after a period of continuous use. In fact, the pituitary gland actually up-regulates to stimulation by Sermorelin which in turn causes the pituitary gland to rejuvenate.
As Sermorelin is 29 amino-acids doesn’t it have to be injected? Is it possible to transport anything across the cells with a molecular weight of 33358 moles? The weight of a molecule is the sum of the weights of its atoms. The unit of such weight is called the dalton. Thus, the molecular weight (MW) of sermorelin is 33,358 daltons. A mole is the quantity of a substance whose weight in grams is equal to the molecular weight of the substance. In other words, a dalton is a measure of weight whereas a mole is a measure of quantity or amount.
Actually, Sermorelin when used clinically is technically a salt, not an amino-acid base. In fact it is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone. An aminoacyl means the radical formed from an amino acid by removal of a hydroxyl (OH) moiety from a carboxyl (COOH) group. During peptide bonding these radicals are joined together, that’s how Sermorelin is synthesized.
As for transport, the chemists at Abbot Laboratories were awarded a US Patent in 1996 (5,487,898) for their work in moving large molecules via sublingual application. Now I realize that the patent is for oligopeptides, (small peptides containing mixtures of amino acids of twenty aminoacyl residues or less). So we're surprised to find out that the method works for some that are even a few residues larger such as sermorelin. This has been achieved with the sublingual Serm-Pro™ carriers- they are not just there as excipients.
Isn’t Sermorelin nothing more than cjc-1295 either a dac version or a non dac version, which when injected has a very short acting life of only 15 minutes? Sermorelin is neither CJC-1295 nor its dac conjugated analog. Some companies are offering these analogues online for use via injection; presumably CJC-1295 is designed to be conjugated with albumin so as to extend its half-life, whereas dac is a molecular modification that extends half-life for several days. However, neither has been reported in the peer-reviewed, (legitimate, non-anecdotal literature) as being superior to Sermorelin for clinical application, nor as safe, i.e., lacking side-effects as Sermorelin does. Also, the relatively short half-life in the case of Sermorelin is irrelevant since the priming effect of daily dosing is cumulative, thereby increasing pituitary reserve and facilitating more youthful, spontaneous neurogenic secretory profiles that sustain muscle mass, decrease fat reserves and all the rest.
Do you know of any studies demonstrating that sublingual administration of Sermorelin does produce higher levels of HGH? A small study has been done but we are not yet allowed to release results pending its publication. Dr. Walker has talked about this subject in some detail however in his latest interview which is uploaded here »
Please note: You should always consult a primary care physician/health practitioner of choice when considering the use of any products for health purposes, especially when undergoing treatment for an existing condition.
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