What are telomeres? Telomeres (te-•lo•meres) are buffers, protective pieces of DNA material at the ends of each and every chromosome in every cell in the body. Imagine a shoelace with the little plastic endpiece that keeps the strings of the lace bound together. This is what a telomere looks like and how it functions. Just as a shoelace unravels if the protective tip is missing, so the genetic material of the chromosomes degrades if not properly protected by telomeres of a certain length
What is Telomerase Activation? Telomerase (te•lo-m•er•ase) is a naturally-occurring enzyme in the body and a vital factor in cell health. It helps maintain the protective telomeres located at the ends of all chromosomes. Scientific studies have shown that controlled activation of telomerase in normal cells can increase telomere length, improve functional capacity, and promote the proliferative lifespan of cells. The Telomerase-Activating potency of the molecule TA-65 has been independently proven in rigorous tests by 3rd party laboratories.
How is TA-65® made? TA-65 is a naturally occurring single molecule found in the small molecule from a medicinal plant. T.A. Sciences has developed a proprietary process to refine and purify TA-65. Our process begins with tons of plant material harvested from selected farms in one small region in China. In our plant extraction facility, the raw small molecule from a medicinal plant root is chopped up and refined. After initial extraction, the base ingredient is further purified and then sent to an outside government testing facility where it is tested for purity, heavy metals, and pesticides. The product is then sent to a FDA certified, state-of-the-art, laboratory for final purification that ends up with 90+% pure TA-65.
Have these products been tested? T.A. SciencesTM follows stringent scientific procedures to back up the safety and efficacy of our products. For more than a decade, we have conducted a series of studies including, most importantly, a 2005 Anti-Aging Trial designed to directly measure the effect of TA-65 when taken internally. In this trial we saw a reduction in the signs of aging from the introduction of TA-65 into the bloodstream. A 125-person safety study showed no negative effects from daily use of TA-65. More exciting news on testing will be available as soon as on-going studies are completed.
Is it safe? TA-65 has been used by hundreds of people since 2005 and not a single adverse side effect or event has been reported. TA-65 is a natural molecule derived from the Astragalus plant, a Chinese herb used since ancient times. Each batch of highly potent TA-65 is vigorously tested for purity and contaminants and is manufactured under GMP conditions in the USA.
Is there real science behind these products? The presence of telomerase and the effects of telomere shortening are so basic to human aging and the maladies of old age that an entirely new branch of biology (Telomere Biology) has sprung up in the last two decades. The science of telomeres and telomerase activation is a new frontier, attracting some of the brightest scientific minds in both the academic and pharmaceutical worlds. To maintain its leadership role in Telomerase Activation, T.A. SciencesTM maintains unique relationships with leading edge biotech firms and opinion leaders in the field of Telomere Biology. Dr. Calvin Harley, who first discovered the link between Telomeres and aging, works closely with T.A. Sciences to integrate the latest scientific discoveries into T.A. Sciences’ products. T.A. Sciences has also established working relationships with several other of the world’s leading Telomere Biologists. For more information on the science behind TA Activation click here »
How does T.A. Sciences assure the quality of its products?
Quality and purity are assured through a series of analytical tests. Here is the process from the beginning to the end of the supply chain:
T.A. Sciences harvests high-potency, naturally grown Astragalus. The raw plant material is refined into a base powder at our exclusive plant-extraction facility.
This refined base material is then further extracted and purified through a proprietary process perfected over more than a decade of research and development to yield the single molecule TA-65 at over 98% purity. Using HPLC/ELSD/CAD, mass spectrometry, and gas chromatography, TA-65 is tested for purity, solvent residue, microbial, heavy metals, and pesticides.
The Purified TA-65 is then sent to an FDA-certified facility for further processing utilizing advanced delivery technology to improve the bioavailability of the TA-65 molecule.
The bioenhanced TA-65 is blended with USP (United States Pharmacopeia) grade GRAS (Generally Recognized As Safe) excipients and encapsulated and packaged at our subcontractor’s state of the art GMP (Good Manufacturing Practices) certified facility. The final product must pass another series of tests including microbial and heavy metals before it can be released.
Through these and other rigorous quality programs, T.A. Sciences can assure our clients that what we say on our label is 100% accurate.
What is the plant from which TA-65 is derived? TA-65 is a naturally occurring molecule found in an ancient Chinese medicinal herb. Well known to most of China’s 1.3 billion people for over 1000 years, this medicinal root can be found in every traditional Chinese herbal shop. Major health benefits from this plant have long been recognized by practitioners in China, but never before has the TA-65 active ingredient been isolated and purified.
If TA-65 is a molecule coming from an ancient medicinal plant and extracts are available in any vitamin shop, why not just buy those inexpensive commercial products? To answer this question, we purchased four commonly available extract products and had them tested to verify how much, if any, TA-65 is present. In all four cases, the testing lab could not detect any TA-65. Their assay is accurate to one part per million. This is not surprising because not only is the TA-65 molecule rare, but extraction processes used by Chinese processing companies normally destroy it. T.A. Sciences uses a proprietary production process that took years of research and over several million dollars to develop. Several patents have been issued to T.A. Sciences over the years related to this technology.
Is TA-65 Scientifically Supported? T.A. Sciences is the first and only company in the world to offer Telomerase-Activating products to combat the effects of cellular aging through leading-edge science. After more than 10 years of rigorous Research and Development, T.A. Sciences is proud to market the unique and potent TA-65 molecule available in TA-65MD®.
Is TA-65 a drug? TA-65 is a nutritional supplement, not a drug. It activates telomerase and this helps keep cells functioning in a normal and healthy way as we age. TA-65 is not a drug and we make no claims that it prevents or treats any disease.
Why not simply buy a medicinal plant extract in a health food store? Medicinal plant extracts can be found in most health food stores, but such products contain little or no TA-65. We tested four commonly available medicinal plant extracts and none of them contained any measureable amounts of TA-65 (the test assay is accurate to one part per million). Our proprietary production process starts with three tons of plant material and ends up with capsules that we guarantee contain 5mg of TA-65.
Is there a risk of unwanted cell proliferation? TA-65 is a single molecule found in the Astragalus plant. Astragalus extracts have been safely consumed by humans for over a thousand years and are available in any vitamin shop. TA-65′s method of action is to activate the enzyme telomerase which in turn affects the telomeres, which are located at the tips of every chromosome in every cell of the body. Telomeres are the cellular clock of aging, every time a cell divides, telomeres get shorter. When telomeres get too short, cells can no longer divide and proliferate; they become old cells. Maintaining telomere health and length allows cells to continue to divide and proliferate for a longer time; they simply live and function longer. However if cells live longer, there is a theoretical concern that they might over proliferate. Therefore, theoretically, TA-65 could stimulate unwanted growth and cell overpopulation. Of course what TA-65 aims to do is to keep healthy cells alive and functioning for as long as possible.
What about the possibility of allowing unhealthy cells to live longer? There is evidence that suggests that TA-65 boosts and strengthens the immune system, which we believe should address or suppress any cell overpopulation. Thus, we believe the overall effect of TA-65 regarding cell proliferation to be positive. Furthermore, we believe that a number of physical changes associated with old age are due to the presence of short telomeres. TA-65 is specifically designed to promote overall cell health and longevity by increasing telomere length or slowing the rate of telomere shortening. When telomerase is activated, cell distress due to shortened telomeres is reduced. In summary, considering the lack of evidence of TA-65 causing unwanted human cell proliferation, we believe the potential beneficial effects of activating telomerase and maintaining healthy tissue function outweigh any theoretical risk. And we practice what we preach; many T.A. Sciences employees are currently taking TA-65. A doctor or professional health care provider who is familiar with Telomere Biology is in the best position to assess if TA-65 is right for you. Products that activate telomerase are on the frontiers of science and before you take TA-65, you should consult your physician or health care provider.
TA-65 sounds too good to be true. How do I know this is not just snake oil like other so-called anti-aging products? TA-65 has been proven by outside, 3rd party laboratories to activate telomerase. Telomerase lengthens telomeres and longer telomeres allow cells to continue to divide and replicate longer. In 2005 we did an Anti-Aging Trial that statistically shows in black and white what real people experienced from TA-65. This was a double-blind, placebo controlled study with data interpreted by Stanford University Ph.D., Dr. Jochen Kumm. T.A. Sciences is solidly grounded in patented telomerase technology and validated by additional controlled studie.
Please note: You should always consult a primary care physician/health practitioner of choice when considering the use of any products for health purposes, especially when undergoing treatment for an existing condition.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or healthcare professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing medication.
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