Indeed clinical trials using Dr.Pierpaoli’s melatonin supplement have supported its efficacy for:
Thus, the “programme of aging” can now be slowed down to a more acceptable rate with Melatonin MZS!
Based on a 2005 research study, supplementing daily with melatonin (along with zinc and selenium) may help stabilize and even improve vision for those with either wet or dry macular degeneration.
Dosage Recommended Guidelines:
Directions: Take half to one (maximum two) 3mg tablets at bedtime only, ideally between 10 PM and 11 PM. Only use Melatonin Zn-Se ® when you are prepared to sleep and have the light switched off, this is because light entering the eye destroys Melatonin or as directed by a medical health professional.
Melatonin MZS Supplemental Facts:
Serving Size: 1 Tablet
Other Ingredients: Avicel, Mannitol, Povidonum, and Magnesium Sterate
Note: Keep in cool, dark conditions, out of the reach of children and consume before the end of the expiration date. Not for use by pregnant or lactating women.
With Melatonin MZS You Really Can Enjoy A Sound Night’s Sleep.
Melatonin is produced by the pineal gland at night to regulate our circadian rhythm (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces resulting in many older people sleeping less and having a lower quality of sleep. Formulated by the world’s foremost melatonin expert Dr Walter Pierpaoli, unlike any other melatonin supplement on the market Melatonin Zn Se mimics the natural night peak of melatonin to leave you feeling refreshed and alert the following day.
Melatonin Zn Se So Much More Than a Sleep Aid.
Melatonin supplements have become widely available but at Antiaging Systems we offer a supplement that goes far beyond the run of the mill melatonin stocked by supermarkets and health shops, no other melatonin offers the endorsement of Dr Pierpaoli or the exact formula used in all of his numerous clinical trials. If you've tried other melatonin and didn’t notice any significant effect, then we highly recommend you try Dr Pierpaoli’s Melatonin MZS for a superior experience.
Effects of melatonin in Age-Related Macular Degeneration.
Age-related macular degeneration (AMD) is the leading cause of severe visual loss in aged people. Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors, to scavenge hydroxyradicals and to protect retinal pigment epithelium (RPE) cells from oxidative damage. Therefore, it is reasonable to think that the physiological decrease of melatonin in aged people may be an important factor in RPE dysfunction, which is a well known cause for initiation of AMD. Our purpose is to explore a new approach to prevent or reverse AMD. We began case control study with a follow-up of 6 to 24 months. One hundred patients with AMD were diagnosed and 3 mg melatonin was given orally each night at bedtime for at least 3 months. Both dry and wet forms of AMD were included. Fifty-five patients were followed for more than 6 months. At 6 months of the trial, the visual acuity had been kept stable in general. Though the follow up time is not long, this result is already better than the otherwise estimated natural course.1,2 The change of the fundus picture was remarkable. Only 8 eyes showed more retinal bleeding and 6 eyes more retinal exudates. The majority had reduced pathologic macular changes. We conclude that the daily use of 3 mg melatonin seems to protect the retina and to delay macular degeneration. No significant side effects were observed.
Melatonin Zn Se and Age Related Macular Degeneration.
Age related macular degeneration (AMD) comes in two forms, wet and dry and is a notoriously difficult disorder to treat but is commonly linked to blindness.
For the patients who continued onward past 6 months and onto 12 months of nightly use of 3mg Melatonin Zn Se the change in their fundus pictures were remarkable, (please note the before and after eye pictures presented within this article in figures 1-3).
Figure 1(above): The left slide shows the eye of a 67 year old male before application, his vision had been deteriorating for 2-years. The right picture shows the same eye 2-months later after daily ingestion of 3mg Melatonin Zn Se tablets. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage.
Figure 2(above): The left slide shows the eye of a 71-year old female with ARMD who after 6-months of 3mg Melatonin Zn Se daily had her vision improve from 0.2 to 0.4 (as indicated in the right slide).
Figure 3(above): A 58 year old male whose visual acuity at the start (left slide) was 0.2. This improved to 0.4 after 6-months of regular use of Melatonin Zn Se. The sub-retinal hemorrhage and exudate was remarkably absorbed.
At the end of the study, of the original 110 eyes tested only 8 eyes showed more retinal bleeding and 6 eyes more retinal exudates, the vast majority had dramatically reduced pathologic macular changes. This was made self-evident by the patients themselves reporting better vision and general ocular experience with improvements to flare, dryness, clarity and comfort.
Whilst the authors called for larger studies to confirm their findings, they concluded that; “melatonin supplementation among the aged population may be beneficial in preventing, relieving or reducing the severity of ARMD, which is one of the leading causes of blindness in the elderly.” What’s more during the entire period (with some patients taking the 3mg tablets every night for 2-years) no significant side effects were observed
Dr. Pierpaoli investigated the possible mechanisms and also the molecules such as selenium and zinc which cooperate and synergize with melatonin in the regulation and re-synchronization of fundamental immunological and hormonal functions which are lost or deranged in the course of aging.
Blue line in Graph: "Plasma" is the normal amount of melatonin found in plasma at those hours of the day.
Why is Melatonin MZS More Effective than Other Melatonin Supplements?
This graph highlights that compares Dr Pierpaoli’s Melatonin MZS formula (Red line)
To the natural release of melatonin (dark Blue line)
And to two common types of melatonin supplements (light blue and green line) to demonstrate that ordinary sublingual melatonin peaks too soon and that time released formulas peak too late.
Melatonin MZS™ is more than “just” Melatonin Tablets
Dr. Pierpaoli has carefully designed his melatonin supplement to give it a number of benefits over “plain regular” versions by including the addition of selenium and zinc. For example, during recent studies and long-term experiments with old rodents, it has been observed that zinc can correct completely aging-dependent immune depression and several other hormonal and metabolic alterations typical of aging. It has been found that the low zinc levels in aging animals can be restored to normal values with nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals.
"Dr. Pierpaoli has carefully designed his melatonin supplement to give it a number of benefits over 'plain regular' versions by including the addition of selenium and zinc."
The mineral Zinc is an essential component in melatonin tablets as it consists of more than 200 enzymes and one of the most relevant trace elements in the body. 8,9 It is thus clear that additional zinc must be supplemented daily to the body of an aging organism with a low zinc balance, in order that melatonin can better exert its anti-aging activities on the entire neuroendocrine and immune systems! This important and novel scientific observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has now resulted into the development of Melatonin Zn Se.
The natural night peak
In addition, a very special feature of Dr. Pierpaoli’s melatonin product is its ability to release melatonin in the same way as the natural release takes place from the brain’s pineal gland. In other words, Melatonin Zn Se mimics nature by producing a night peak release of melatonin in the same way as is normal in youth. Normal and especially sublingual and time-released versions of melatonin are unable to do this, only Dr. Pierpaoli’s Melatonin Zn Se tablets has been designed, tried and tested for this purpose.
"...a very special feature of Dr. Pierpaoli’s melatonin product is its ability to release melatonin in the same way as the natural release takes place from the brain’s pineal gland."
So whilst melatonin plays the master role for reactivation and restoration of its natural night peak to juvenile levels, (thus resulting into normalization of all measurable immunological and endocrine functions in the course of aging). The positive aging-postponing, metabolic and immunological effects of Melatonin Zn Se can be easily measured by anybody by means of a normal periodic check-up.
Please note: You should always consult a primary care physician/health practitioner of choice when considering the use of any products for health purposes, especially when undergoing treatment for an existing condition.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or healthcare professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing medication.
*The information on this website is for informational and educational purposes only. It is not an attempt by the writers or publisher to diagnose or prescribe, nor should it be construed to be such. The information is not intended to replace medical advice offered by physicians. Readers are hereby encouraged to consult with a licensed health care professional concerning the information presented, which has been received from sources deemed reliable, but no guarantees, expressed or implied, can be made regarding the accuracy of same. Therefore, readers are also encouraged to verify for themselves and to their own satisfaction the accuracy of all reports, recommendations, conclusions, comments, opinions, or anything else published herein before making any kind of decisions based upon what they have read. If you have a medical condition, please consult your medical practitioner. Vita Stream, INC will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising from the use or misuse of any products, materials or information published.
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Featured positive reviews:
Melatonin MZS 01/14/2016
I have dry ARMD and have been taking Melatonin MZS
(Dr. Pierpaoli's original formula) for 6 months. I have just been to my optometrist for a scan to check my condition. The scan shows signs of reversal! My quality of sleep has also improved but my motivation for taking Melatonin MZS was for the benefit of my ARMD. I will be checked again in 6 months and will provide a further update. I have no hesitation in recommending this melatonin supplement which I have only ordered from Vita-Stream as it is the original formula.